Effect of early application of hypertonic saline on secondary brain injury after traumatic brain injury

Abstract

To investigate the effect of early application of hypertonic saline on secondary brain
injury after traumatic brain injury. Methods 50 patients with secondary brain injury after
traumatic brain injury who were hospitalized in our hospital from January 2021 to
October 2022 were respectively selected as the study objects. They were divided into
control group (25 cases) and observation group (25 cases) according to the treatment
method. The control group was treated with mannitol in the early stage, and the
observation group was treated with hypertonic saline in the early stage. Optic nerve
sheath diameter(ONSD）and cerebral perfusion pressure (CPP); Neuron specific
enolase (NSE) level; Serum interleukin-6 (IL-6), interleukin-8 (CRP) levels were
compared between the two groups before and after treatment. Results Compared with
that before treatment, ONSD in the two groups decreased significantly and CPP
increased significantly after treatment, while ICP in the observation group was
significantly lower than that in the control group, and CPP was significantly higher than
that in the control group (P<0.05); Compared with before treatment, the levels of NSE
in the two groups decreased significantly after treatment, while the levels of NSE in the
observation group were significantly lower than those in the control group (P<0.05);
Compared with that before treatment, the levels of serum IL-6 and CRP in the two
groups decreased significantly after treatment, while the levels of serum IL-6 and CRP
in the observation group were significantly lower than those in the control group